Selenium Sulphide for Treating Dandruff
What is Selenium Sulfide (Selenium Disulfide)?
Selenium sulfide is an antifungal agent and the active ingredient in many medicated shampoos and lotions. It is commonly used for the treatment of dandruff and seborrheic dermatitis, as well as certain fungal skin infections. This ingredient works on both hair and scalp by controlling fungal growth and restoring scalp balance.
This is not an ingredient used by Hairetic in our range, as we believe this ingredient can be too strong for regular use, and may not suitable for a very wide audience. We believe a balance or Natural Active ingredients alongside Piroctone Olamine is the perfect mix.

How Does Selenium Sulfide Work?
Selenium sulfide works by disrupting the function of fungal cells, interfering with the production of enzymes and proteins needed for survival. This process effectively kills the fungus and reduces symptoms such as itching and flaking. In addition, selenium sulfide slows down the rate of skin cell turnover, preventing excessive flake buildup on the affected area.
If you’re wondering, “how does selenium sulfide work?”, the answer is that it directly targets Malassezia yeast — the underlying cause of dandruff — while helping the body to treat inflammation naturally.

Benefits of Selenium Sulfide for Dandruff
- Antifungal action: Targets fungi responsible for dandruff and seborrheic dermatitis.
- Relieves symptoms: Reduces itching, flaking, redness, and skin irritation.
- Improves hair and scalp health: Restores scalp balance for a healthier environment.
- Long-lasting results: Regular use of selenium sulfide shampoo provides extended relief.
How to Use Selenium Sulfide for Dandruff Treatment
Selenium sulfide is available as shampoos, foams, and lotions. For the treatment of dandruff, apply selenium sulfide shampoo 2–3 times per week. Massage into the affected area of the scalp and leave for several minutes before rinsing. Avoid contact with eyes and broken skin. Always follow the instructions on the packaging and speak with your GP or dermatoligst if unsure.
Many people compare selenium sulfide with over-the-counter options like Head & Shoulders, which often contain zinc pyrithione (banned in the EU) or piroctone olamine. While both are effective, selenium sulfide is considered stronger for moderate to severe dandruff and seborrheic dermatitis.
Potential Side Effects
While safe for most, some users report side effects such as mild skin irritation, dryness, temporary hair discoloration, or rare cases of hair loss. An allergic reaction is uncommon but possible. If severe reported side effects occur, stop use immediately and consult a medical professional.

Clinical Studies on Selenium Sulfide
- A double-blind study of 2.5% selenium sulfide shampoo in tinea capitis: Published in the Journal of the American Academy of Dermatology. Results showed high effectiveness in reducing fungal growth.
- Comparison of selenium sulfide 1% vs ketoconazole 2%: Both reduced dandruff severity, with selenium sulfide showing fewer side effects.
- Randomized trial of selenium sulfide lotion for seborrheic dermatitis: Results showed significant improvement in scalp condition with minimal adverse effects.
Additional Information on Selenium Sulfide
Selenium sulfide has been used for decades as a proven treatment for scalp conditions. Unlike some milder over-the-counter solutions, it is classified as a therapeutic active ingredient and is widely recommended by dermatologists. It not only treats dandruff but also helps with skin infection control, reducing the spread of fungal organisms on the scalp and body. This makes it valuable for people dealing with persistent dandruff and seborrheic dermatitis that do not respond to standard shampoos.
Compared to natural remedies such as tea tree oil or apple cider vinegar, selenium sulfide is backed by more scientific evidence and clinical studies. It is especially effective on the hair and scalp, where fungal growth is often localized. By keeping the affected area free of excess yeast, it improves both scalp comfort and cosmetic appearance.
For patients concerned about side effects, most reported side effects are mild and reversible. Concerns about hair discoloration or hair loss are rare, and usually only occur if directions are not followed properly. To minimize risks, avoid leaving the shampoo on longer than directed, and rinse thoroughly.
Dermatologists often recommend rotating selenium sulfide with other medicated shampoos, such as those containing ketoconazole or zinc pyrithione, to prevent fungal resistance and improve long-term results. This strategy is useful for individuals with chronic dandruff and seborrheic dermatitis.
Selenium sulfide is one of the more effective ingredients for the treatment of dandruff. By reducing fungal growth and controlling excess skin shedding, it delivers significant improvements in both scalp health and quality of life.

Key Websites and Sources
- NHS UK – https://www.nhs.uk/
- NICE – https://www.nice.org.uk/
- British Association of Dermatologists – https://www.bad.org.uk/
- American Academy of Dermatology – https://www.aad.org/
- National Institute of Arthritis and Musculoskeletal and Skin Diseases – https://www.niams.nih.gov/
- DermNet NZ – https://dermnetnz.org/
- Mayo Clinic – https://www.mayoclinic.org/
- WebMD – https://www.webmd.com/
- PubMed – https://pubmed.ncbi.nlm.nih.gov/
- The Cochrane Library – https://www.cochranelibrary.com/
- Journal of the American Academy of Dermatology – https://www.jaad.org/
Frequently Asked Questions
How long does it take for selenium sulfide to work?
Most people see improvement in dandruff and seborrheic dermatitis within 1–2 weeks of regular use.
Can selenium sulfide shampoo cause hair loss?
Hair loss is rare but has been reported. It usually resolves when treatment is stopped.
Is selenium sulfide safe for colored hair?
It may cause hair discoloration in some dyed or permed hair. Patch test on a small section first.
What are the common side effects of selenium sulfide?
Most reported side effects are mild and include dryness, itching, or temporary changes in hair texture.
Is selenium sulfide better than Head & Shoulders?
Head & Shoulders contains zinc pyrithione, which is effective for mild dandruff. Selenium sulfide is stronger and often used when dandruff and seborrheic dermatitis are more severe.